Understanding The Difference Between Piles, Fissure and Fistula: Common Anorectal Conditions Explained Experiencing pain, bleeding, swelling or discomfort during bowel movements often leads to concern, particularly when it is unclear whether the issue is piles, fissure or fistula. Although these conditions affect the anal and rectal region, they are different waiting for link from Web 2.0 Blogs (28)